The Hhip Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to hedgehog interacting protein, and HHIP. This antibody recognizes Human, Mouse, and Rat antigen. The Hhip Antibody has been validated for the following applications: EIA, Immunoassay, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Western Blot.
Description
Function: Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family.
Subcellular Location: Cell membrane>Peripheral membrane protein. Secreted. Note: The last 22 C-terminal amino acids may participate in cell membrane attachment.Cytoplasm.
Tissue Specificity: Widely expressed in fetal and adult tissues. Highest expression in adult heart, liver and pancreas, and in fetal kidney.
Subunit Structure: Interacts with all three hedgehog family members, SHH, IHH and DHH.
Similarity: A flexible loop interacts with the SHH zinc binding site and contributes to zinc binding.Belongs to the HHIP family